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Journal of the Korean Neurological Association 1995;13(2): 362-366.
조기 난소부전과 갑상선 자가항체를 동반한 중증 근무력증 1례
함동석, 장세희, 윤영철, 김우정, 권오상, 박형무, 김두응, 이광우
중앙대학교 신경과. 산부인과, 서울대학교 신경과
A case of Myasthenia Gravis associated with Premature ovarian ?failure and thyroid autoanibodies
Dong Suk Ham, M.D., Sei Hee Chang, M.D., Young Chul Youn, M.D., Woo Jung Kim, M.D., Oh Sang Kwon, M.D., Hyoung Moo Park M.D., Doo Eung Kim, M.D., Kwang Woo Lee, M.D.
Department of Neurology, Obstetrics &Gynecology, College of Medicine, Chungang University, Department of Neurology, Seoul National University, College of Medicine
Abstract
Myasthenia gravis (MG) is regarded as autoimmune disorder of neuromuscular transmission and apparently is due to formation of humoral antibody that cross-link to acetylcholine receptor at skeletal muscle end plate. Patients with autoimmune diseases often have circulating antibodies to a variety of different autoantigens and show a variety of manifestations of autoimmune diseases in more than one organ. Therefore, MG patients frequently have manifestations of autoimmune diseases such as thyroid disease, rheumatoid arthritis and systemic lupus erythematosus. But MG in association with premature ovarian failure (POF) rarely has been described. A case of MG with POF and thyroid autoantibodies was experienced and presented with a brief review of literature. Key Words : Myasthenia Gravis, Premature Ovarian Failure, Thyroid Autoimmunity