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Journal of the Korean Neurological Association 1995;13(2): 311-318.
Gliomatosis cerebri9 예에 대한 임상적, 방사선학적, 병리학적 고찰
박경석, 전범석, 이광우, 노재규, 이상복, 명호진, 지제근
서울대학교 신경과. 해부병리학교실
Gliomatosis cerebri ; clinical, radiological, and pathological ?analysis of nine cases
K.S. Park, M.D., B.S. Jeon, M.D., K.W. Lee, M.D., J.D. Roh, M.D., S.B. Lee, M.D., H.J. Myung, M.D., J.G. Chi. M.D.
Department of Neurology, Pathology, Seoul National University College of Medicine
Abstract
Gliomatosis cerebri is a rare tumor of neuroepithelial origin presenting as deterioration of cognitive function, seizure, and psychomotor retardation. Since 1988, we have seen nine cases of gliomatosis confirmed by biopsy. Headache, seizure, visual disturbance, dementia, motor weakness were the initial predominating clinical features in these cases. MRI was much better in delineating the extent of tumors by showing ill-defined high signal intensity on T2-weighted images. Histological examination of brain biopsy disclosed a diffuse proliferation of neoplastic glial cells infiltrating into well-preserved underlying cytoarchitecture. The diagnosis of glimatosis cerebri was formerly made only at autopsy. However, recent improvements in neuroimaging techniques and biopsy now allow for antemortem diagnosis.
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