A Case of Suspected Post-Irradiation Delayed Necrotizing ?Leukoencephalopathy

J Korean Neurol Assoc > Volume 12(3); 1994 > Article

Journal of the Korean Neurological Association 1994;12(3): 534-541.

방사선 손상으로 사료되는 지연괴사성 백질뇌병증 1예

나정균, 정원영,조경원

조선대학교 신경과.

A Case of Suspected Post-Irradiation Delayed Necrotizing ?Leukoencephalopathy

Jeong Gyun Na, M.D., Won Young Jung, M.D., Kyung Won Cho, M.D.

Department of Neurology, Chosun University Medical College

Abstract

Therapeutic irradiation may produce a variety of adverse side effects on the central and the peripheral nervous systems. These adverse effects are divided into two main groups ; transient and permanent. Four major clinical syndromes have been described in relation to permanent radiation injury of the nervous system : encephalopathy, cranial neuropathy, myelopathy, and peripheral neuropathy. Among them, delayed encephalopathy represents the major hazard in CNS irradiation. The characteristic MR imaging pattern of radiation induced delayed necrotizing leukoencephalopathy is symmetric, high-signal foci on T2WI in the periventricular white matter. We report a case of suspected post-irradiation leukoencephalopathy showed progressive mental change, quadriparesis, and urinary incontinence with characteristic MR findings who had taken therapeutic irradiation 12 months ago.