Pathogenetic Correlations of Anti-Ganglioside Antibody in ?Guillain-Barre Sydrome

J Korean Neurol Assoc > Volume 12(3); 1994 > Article

Journal of the Korean Neurological Association 1994;12(3): 474-483.

Guillain-Barre증후군에서 항-ganglioside항체의 병인적 인과관계에 ?대한 연구

이근호, 이성현,이상복,이광우

단국대학교 신경과. 서울대학교 신경과.

Pathogenetic Correlations of Anti-Ganglioside Antibody in ?Guillain-Barre Sydrome

Geun-Ho Lee, M.D., Sung-Hyun Lee, M.D., Sang-Bok Lee, M.D., Kwang-Woo Lee, M.D.

Department of Neurology, College of Medicine, Seoul National University, Department of Neurology, College of Medicine, Dan Kook University

Abstract

Guillain-Barre syndrome (GBS) is characterized by similar clinical manifestations which are caused by several factors. But the autoimmune theories seems to be important for understanding its pathomechanism. Recently antibodies to neutral glycolipid, anti-GM1 antibodies, and anti-MAG antibodies have been implicated for possible causative factors in some GBS(Iiyas et al. 1998 ; Koski et al. 1989 ; Yu et al. 1990). The author performed the study to understand the pathogenetic correlation of anti-GM1 antibodies whth GBS. The anti-GM1titers were checked by the ELISA method in 30 patients with GBS, 30 other neurological diseases (OND) and 30 normal subjects. All the serafrom GBS patients were taken during the period of acute exacerbation or before 10 to 20 days after the initiation of clinical disability. The positive IgM-type anti-GM1 antibodies were found in 10 out 30 GBS patients (33.3%), and 6 out of 30 OND patients(20%), and none of 30 normal subjects. Clinically, the relative severe course were found in 4 out of 10 (40.0%) antibody-positive and in 4 out of 20 (20.0%) antibody-negative GBS patients,which was not significant statistically. Therefore it is concluded that there could be some correlations of anti-GM1 antibodies with GBS, which needs further investigation.