| 섬유소 용해력의 계절별 변화에 대한 연구 |
| 박정민, 방차옥,이태경,윤신구,성기범,오건세,안무영,양동호,신현길 |
| 순천향대학교 신경과, 내과. |
| Seasonal Variation of Fibrinolytic Activity |
| Jung-Min Park, M.D., Cha-Ok Bang, M.D., Tae-Kyeong Lee, M.D., Shin-Gu Yoon, M.D., Ki-Bum Sung, M.D., Gun-Se Oh, M.D., Mu-Young Ahn, M.D., Dong-Ho Yang, M.D., Hyun-Kil Shin M.D. |
| Department of Neurology, Internal Medicine, College of Medicine, Soonchunhyang University |
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| Abstract |
Background and Purpose: Among the many factors having influence on seasonal incidence of thrombotic disease, we studied the seasonal variation of fibrinolytic activity, which might be thought to have influence on seasonal incidence of thrombotic disease.
Subject and Method: Seasonal plasma tissue type plasminogen activator (t-PA) and
euglobulin fibrinolytic activity (EFA) were measured in 18 male and 22 female normal
volunteers during a year. Result: The level of t-PA was higher in winter than in spring
(p<0.05), but was not significantly different in the other couples of four seasons. The
level of EFA was higher in winter than in summer and in autumn (p<0.01), and was
slightly higher in winter than in spring without significance. The level of EFA was
higher in spring than in summer (p<0.05). There was no correlation between the level
of t-PA and that of EFA in any of the seasons.
Conclusion: The fibrinolytic activity is
higher at lower temperature than at higher temperature. Thus, it seems that a rise in
fibrinolytic activity in cold weather counters certain changes which make a thrombotic
event. |
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