Acute Isoniazid Intoxication-As an Unusual Cause of Fatal Status Epilepticus-

J Korean Neurol Assoc > Volume 11(2); 1993 > Article

Journal of the Korean Neurological Association 1993;11(2): 286-288.

간질 중첩증으로 발현된 급성 Isoniazid 중독증

유경호, 김상윤,이병철

한림대학교 신경과.

Acute Isoniazid Intoxication-As an Unusual Cause of Fatal Status Epilepticus-

Kyung-Ho Eyu, M.D., Sang-Yoon Kim, M.D., Byung-Chul Lee, M.D

Department of Neurology, College of Medicine Hallym University

Abstract

Isoniazid (INH), a hydrazide of isonicotinic acid, has been used for more than 30 years for the treatment of tuberculosis and is one of the most effective anti-tuberculous agents so far. In spite of the widespread use of INH, very few accidental or suicidal poisonings have been reported, Acute INH intoxication is characterized by hyperpyrexia, respiratory distress, coma seizure, metabolic acisosis, hyperglycemia and acetonuria Especially metabolic acidosis is not corrected by alkali therapy in which usual dose of bicarbonate supply, and seizure attacks also has not controlled by common anti-epileptic drugs, so it needed a large quantity of intravenous pyridoxine and diazepam infusion. This report describes an adult who ingested large amount of INH with the intent of suicide and was presented with the fatal status epilepticus and severe metabolic acidosis.