The Measurement of Plasma B-Endorphin in Acute Carbon Monoxide ?Poisoning

J Korean Neurol Assoc > Volume 6(2); 1988 > Article

Journal of the Korean Neurological Association 1988;6(2): 176-179.

급성 일산화탄소중독시 혈장 B-Endorphin치의 변화에 대한 연구

김원천, 최경규,이명식,최일생,김진수

연세대학교 내과, 신경과. 이화여자대학교 내과.

The Measurement of Plasma B-Endorphin in Acute Carbon Monoxide ?Poisoning

Won-Tsen kim,M.D.,Kyung-Gyu Choi,M.D.Myung-Sik Lee,M.D.,Il-Saing Choi,M.D.Jin-Soo Kim,M.D.

Department of Internal medicine,Wonju Medical college, Yonsei University Department of Internal medicine, college of medicine, Ewha's Woman's University Department of Internal medicine, college of medicine, Yonsei University

Abstract

pathophysiology of acute carbon monoxide poisoning is not clear. It is generally accepted that hypoxic and/or anoxic insult is very significant role in the pathophysiology of acute acrbon monoxide poisoning, but many arguments are documented especially focal hypoxia or metabalic acidosis within brain parenchyme. In sofar such a focal change seems to be largely depend upon focal change of neuroendocrine substances including B-endorphin. Also B-endorphin is known to be responsble to the pathogenesis of cerebral ischemia. Though the possible relationship between the alteration of level of B-endorphin and hypoxia, it is seldom to pay attention to the role of B-endorphin in carbon monoxide intoxication. We measured plasma B-endorphin in acute carbon monoxide intoxication and compared with the value of control group. There was no difference between control group and acute carbon monoxide poisoning group, the possible role of B-endorphin in acute carbon monoxide poisoning should not be excluded. We suggest the more comprehensive and newly programmed study seems to need for clarifying the possible role of B-endorphin in acute carbon monoxide poisoning.