A Case of Podophyllum Toxicity with Peripheral Polyneuropathy

J Korean Neurol Assoc > Volume 3(2); 1985 > Article

Journal of the Korean Neurological Association 1985;3(2): 298-301.

podophyllum 중독에 의한 다발성 말초신경병증 1예

이상도, 서정규, 박영춘

계명대학교 신경과.

A Case of Podophyllum Toxicity with Peripheral Polyneuropathy

Sang-Do Lee, M.D.,Young-Choon Park, M.D., Jung-Kyue Seo, M.D.

Department of Neurology, Kyemyung University

Abstract

A case is reported ofsystemic toxicity by topically applied podophyllin. The patient was a 18-year-old girl who was treated at private gynecological clinic with 25% podophyllin resin for multiple vulval condyloma acuminata. Her apparent podophyllin toxicity begun 4 hours after topical application, presenting gastrointestinal symptoms such as nausea, vomiting, diarrhea and abdominal distension, followed by tingling sensation on hands and feet with motor weakness predominantly of distal limbs. She had never experienced disturbance of consciousness or other CNS symptoms. The symptoms of severe peripheral neuropathy had been improved by 72 days followup when she had mild impairement of vibration and position sense and mild dorsiflexion weakness of the feet.